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-Structure paper
Title | Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 109, Page 4058-4063, Year 2012 |
Publish date | Mar 29, 2011 (structure data deposition date) |
![]() | No, J.H. / de Macedo Dossin, F. / Zhang, Y. / Liu, Y.L. / Zhu, W. / Feng, X. / Yoo, J.A. / Lee, E. / Wang, K. / Hui, R. ...No, J.H. / de Macedo Dossin, F. / Zhang, Y. / Liu, Y.L. / Zhu, W. / Feng, X. / Yoo, J.A. / Lee, E. / Wang, K. / Hui, R. / Freitas-Junior, L.H. / Oldfield, E. |
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Methods | X-ray diffraction |
Resolution | 2.61 - 2.9 Å |
Structure data | ![]() PDB-3rbm: ![]() PDB-3ryw: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-B73: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-K9H: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / ALPHA-HELICES / ISOPRENE BIOSYNTHESIS / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE / geranylgeranyl diphosphate synthase / BPH-811 |