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Structure paper

TitleA P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Journal, issue, pagesPlos Pathog., Vol. 8, Page e1002553-e1002553, Year 2012
Publish dateJan 19, 2011 (structure data deposition date)
AuthorsBosch, D.E. / Willard, F.S. / Ramanujam, R. / Kimple, A.J. / Willard, M.D. / Naqvi, N.I. / Siderovski, D.P.
External linksPlos Pathog. / PubMed:22383884
MethodsX-ray diffraction
Resolution2.797 - 3 Å
Structure data

PDB-3qe0:
A Galpha-i1 P-loop mutation prevents transition to the activated state
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-3qi2:
A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
Method: X-RAY DIFFRACTION / Resolution: 2.797 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / KB752 / Ras-like domain / all-helical domain / arginine finger / lipoprotein / transducer / GTPase activity / GTP binding / nucleotide binding / ADP-ribosylation / RGS14 GoLoco / GoLoco motif / guanine nucleotide dissociation inhibitor

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