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TitleIdentification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 14289-14300, Year 2012
Publish dateNov 26, 2011 (structure data deposition date)
AuthorsPunchihewa, C. / Inoue, A. / Hishiki, A. / Fujikawa, Y. / Connelly, M. / Evison, B. / Shao, Y. / Heath, R. / Kuraoka, I. / Rodrigues, P. ...Punchihewa, C. / Inoue, A. / Hishiki, A. / Fujikawa, Y. / Connelly, M. / Evison, B. / Shao, Y. / Heath, R. / Kuraoka, I. / Rodrigues, P. / Hashimoto, H. / Kawanishi, M. / Sato, M. / Yagi, T. / Fujii, N.
External linksJ. Biol. Chem. / PubMed:22383522
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3vkx:
Structure of PCNA
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-T3:
3,5,3'TRIIODOTHYRONINE / hormone*YM

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / nuclei

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