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Structure paper

TitleStructural Insights Into Antibody Sequestering and Neutralizing of Na+-Channel & [Alpha]-Type Modulator from Old-World Scorpion Venom
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 14136-, Year 2012
Publish dateJan 10, 2012 (structure data deposition date)
AuthorsFabrichny, I.P. / Mondielli, G. / Conrod, S. / Martin-Eauclaire, M.F. / Bourne, Y. / Marchot, P.
External linksJ. Biol. Chem. / PubMed:22371498
MethodsX-ray diffraction
Resolution1.6 - 2.3 Å
Structure data

PDB-4aeh:
Crystal structure of the anti-AaHI Fab9C2 antibody
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-4aei:
Crystal structure of the AaHII-Fab4C1 complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

Source
  • mus musculus (house mouse)
  • androctonus australis hector (scorpion)
KeywordsIMMUNE SYSTEM / ANDROCTONUS / ALPHA-TOXIN / COMBINING SITE / EPITOPE / PHARMACOLOGICAL SITE / VENOM / VOLTAGE- ACTIVATED SODIUM CHANNEL / SCORPION / IMMUNE SYSTEM/TOXIN / IMMUNE SYSTEM-TOXIN COMPLEX / CONFORMATIONAL REARRANGEMENT / VOLTAGE-ACTIVATED SODIUM CHANNEL

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