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TitleTargeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 134, Page 4465-, Year 2012
Publish dateJun 15, 2011 (structure data deposition date)
AuthorsBuckley, D.L. / Van Molle, I. / Gareiss, P.C. / Tae, H.S. / Michel, J. / Noblin, D.J. / Jorgensen, W.L. / Ciulli, A. / Crews, C.M.
External linksJ. Am. Chem. Soc. / PubMed:22369643
MethodsX-ray diffraction
Resolution2.8 - 2.9 Å
Structure data

PDB-3zrc:
pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3zrf:
pVHL54-213-EloB-EloC complex_apo
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-L8B:
(4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / TUMOUR SUPRESSOR PROTEIN / CHRONIC ANEAMIA TRE E3 TREATMENT / E3 UBIQUITIN LIGASE / CHRONIC ANEAMIA TREATMENT

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