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TitlePotent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn(2+) fluorophores, kinetic, and X-ray crystallographic study.
Journal, issue, pagesJ. Biol. Inorg. Chem., Vol. 17, Page 517-529, Year 2012
Publish dateAug 24, 2011 (structure data deposition date)
AuthorsHanaya, K. / Suetsugu, M. / Saijo, S. / Yamato, I. / Aoki, S.
External linksJ. Biol. Inorg. Chem. / PubMed:22311113
MethodsX-ray diffraction
Resolution1.29 Å
Structure data

PDB-3vh9:
Crystal structure of Aeromonas proteolytica aminopeptidase complexed with 8-quinolinol
Method: X-RAY DIFFRACTION / Resolution: 1.29 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HQY:
quinolin-8-ol

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-SCN:
THIOCYANATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • vibrio proteolyticus (bacteria)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / 8-Quinolinol / Dinuclear zinc hydrolases / Aminopeptidase / HYDROLASE-HYDROLASE INHIBITOR complex

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