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Structure paper

TitleStructural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Journal, issue, pagesNat. Immunol., Vol. 13, Page 283-289, Year 2012
Publish dateNov 26, 2011 (structure data deposition date)
AuthorsBulek, A.M. / Cole, D.K. / Skowera, A. / Dolton, G. / Gras, S. / Madura, F. / Fuller, A. / Miles, J.J. / Gostick, E. / Price, D.A. ...Bulek, A.M. / Cole, D.K. / Skowera, A. / Dolton, G. / Gras, S. / Madura, F. / Fuller, A. / Miles, J.J. / Gostick, E. / Price, D.A. / Drijfhout, J.W. / Knight, R.R. / Huang, G.C. / Lissin, N. / Molloy, P.E. / Wooldridge, L. / Jakobsen, B.K. / Rossjohn, J. / Peakman, M. / Rizkallah, P.J. / Sewell, A.K.
External linksNat. Immunol. / PubMed:22245737
MethodsX-ray diffraction
Resolution1.67 - 2.712 Å
Structure data

PDB-3utp:
1E6 TCR specific for HLA-A*0201-ALWGPDPAAA
Method: X-RAY DIFFRACTION / Resolution: 2.574 Å

PDB-3utq:
Human HLA-A*0201-ALWGPDPAAA
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

PDB-3uts:
1E6-A*0201-ALWGPDPAAA Complex, Monoclinic
Method: X-RAY DIFFRACTION / Resolution: 2.712 Å

PDB-3utt:
1E6-A*0201-ALWGPDPAAA Complex, Triclinic
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / T cell receptor / Type I Diabetes / Major Histocompatibility Complex / Human Leukocyte antigen

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