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Structure paper

TitleTrypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors.
Journal, issue, pagesPlos Pathog., Vol. 8, Page e1002474-e1002474, Year 2012
Publish dateSep 2, 2010 (structure data deposition date)
AuthorsBuschiazzo, A. / Muia, R. / Larrieux, N. / Pitcovsky, T. / Mucci, J. / Campetella, O.
External linksPlos Pathog. / PubMed:22241998
MethodsX-ray diffraction
Resolution3.4 Å
Structure data

PDB-3opz:
Crystal structure of trans-sialidase in complex with the Fab fragment of a neutralizing monoclonal IgG antibody
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-HOH:
WATER

Source
  • trypanosoma cruzi (eukaryote)
  • mus musculus (house mouse)
Keywordshydrolase/immune system / six-bladed beta-propeller neuraminidase immunoglobulin domain / viral protein-immune system complex / hydrolase-immune system complex

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