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TitleInsights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.
Journal, issue, pagesBiochemistry, Vol. 51, Page 7-9, Year 2012
Publish dateDec 7, 2011 (structure data deposition date)
AuthorsPallan, P.S. / Yu, J. / Allerson, C.R. / Swayze, E.E. / Seth, P. / Egli, M.
External linksBiochemistry / PubMed:22229409
MethodsX-ray diffraction
Resolution1.24 - 1.53 Å
Structure data

PDB-3v06:
Crystal structure of S-6'-Me-3'-fluoro hexitol nucleic acid
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

PDB-3v07:
Crystal structure of R-6'-Me-3'-fluoro hexitol nucleic acid
Method: X-RAY DIFFRACTION / Resolution: 1.24 Å

Chemicals

ChemComp-SR:
STRONTIUM ION

ChemComp-HOH:
WATER

KeywordsDNA / A-form DNA / 3'-fluoro hexitol nucleic acid / FHNA / S-6'-Me-FHNA / antisense oligonucleotides / R-6'-Me-FHNA

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