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TitleAutoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 20579-20584, Year 2011
Publish dateJun 1, 2011 (structure data deposition date)
AuthorsKobashigawa, Y. / Tomitaka, A. / Kumeta, H. / Noda, N.N. / Yamaguchi, M. / Inagaki, F.
External linksProc. Natl. Acad. Sci. USA / PubMed:22158902
MethodsNMR (solution) / X-ray diffraction
Resolution3.1 Å
Structure data

PDB-2ldr:
Solution structure of Helix-RING domain of Cbl-b in the Tyr363 phosphorylated form
Method: SOLUTION NMR

PDB-3vgo:
Crystal structure of the N-terminal fragment of Cbl-b
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / E3 ligase / ubiquitin / RING domain / MEROHEDRAL TWINNING

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