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Structure paper

TitleAllosteric antibody inhibition of human hepsin protease.
Journal, issue, pagesBiochem. J., Vol. 442, Page 483-494, Year 2012
Publish dateJul 22, 2011 (structure data deposition date)
AuthorsKoschubs, T. / Dengl, S. / Durr, H. / Kaluza, K. / Georges, G. / Hartl, C. / Jennewein, S. / Lanzendorfer, M. / Auer, J. / Stern, A. ...Koschubs, T. / Dengl, S. / Durr, H. / Kaluza, K. / Georges, G. / Hartl, C. / Jennewein, S. / Lanzendorfer, M. / Auer, J. / Stern, A. / Huang, K.S. / Packman, K. / Gubler, U. / Kostrewa, D. / Ries, S. / Hansen, S. / Kohnert, U. / Cramer, P. / Mundigl, O.
External linksBiochem. J. / PubMed:22132769
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-3t2n:
Human hepsin protease in complex with the Fab fragment of an inhibitory antibody
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Type II transmembrane serine protease / SRCR domain / Substrates include pro-hepsin / pro-HGF / Laminin-332 / Transmembrane

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