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TitleMechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 51, Page 482-, Year 2012
Publish dateMay 13, 2011 (structure data deposition date)
AuthorsWu, B. / Szymanski, W. / Wybenga, G.G. / Heberling, M.M. / Bartsch, S. / De Wildeman, S. / Poelarends, G.J. / Feringa, B.L. / Dijkstra, B.W. / Janssen, D.B.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:22113970
MethodsX-ray diffraction
Resolution2.18 Å
Structure data

PDB-2yii:
Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-FMT:
FORMIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • taxus wallichiana var. chinensis (Chinese yew)
KeywordsLYASE

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