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Structure paper

TitleCrystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation.
Journal, issue, pagesBiochemistry, Vol. 50, Page 10195-10202, Year 2011
Publish dateJul 5, 2011 (structure data deposition date)
AuthorsPozzi, N. / Chen, Z. / Zapata, F. / Pelc, L.A. / Barranco-Medina, S. / Di Cera, E.
External linksBiochemistry / PubMed:22049947
MethodsX-ray diffraction
Resolution1.9 - 2.2 Å
Structure data

PDB-3sqe:
Crystal structure of prethrombin-2 mutant S195A in the alternative form
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3sqh:
Crystal structure of prethrombin-2 mutant S195A in the the open form
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Serine protease / Prethrombin-2

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