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TitleSelective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen.
Journal, issue, pagesAcs Chem. Biol., Vol. 7, Page 185-, Year 2012
Publish dateJul 12, 2011 (structure data deposition date)
AuthorsKwiatkowski, N. / Deng, X. / Wang, J. / Tan, L. / Villa, F. / Santaguida, S. / Huang, H.C. / Mitchison, T. / Musacchio, A. / Gray, N.
External linksAcs Chem. Biol. / PubMed:21992004
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-3ztx:
Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen.
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-ZTX:
2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsTRANSFERASE/CELL CYCLE / TRANSFERASE-CELL CYCLE COMPLEX / TRANSFERASE / TAXOL-INDUCED CHECKPOINT INHIBITOR

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