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TitleFragment based discovery of a novel and selective PI3 kinase inhibitor.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 6586-6590, Year 2011
Publish dateJul 27, 2011 (structure data deposition date)
AuthorsHughes, S.J. / Millan, D.S. / Kilty, I.C. / Lewthwaite, R.A. / Mathias, J.P. / O'Reilly, M.A. / Pannifer, A. / Phelan, A. / Stuhmeier, F. / Baldock, D.A. / Brown, D.G.
External linksBioorg. Med. Chem. Lett. / PubMed:21925880
MethodsX-ray diffraction
Resolution2.5 - 2.8 Å
Structure data

PDB-3zvv:
Fragment Bound to PI3Kinase gamma
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3zw3:
Fragment based discovery of a novel and selective PI3 Kinase inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-XAZ:
5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-amine

ChemComp-HOH:
WATER

ChemComp-ZW3:
N-{6-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]imidazo[1,2-a]pyridin-2-yl}acetamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PI3 KINASE GAMMA

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