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Structure paper

TitleStructure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 5480-5486, Year 2011
Publish dateJun 13, 2011 (structure data deposition date)
AuthorsScheiper, B. / Matter, H. / Steinhagen, H. / Bocskei, Z. / Fleury, V. / McCort, G.
External linksBioorg. Med. Chem. Lett. / PubMed:21840218
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3sfc:
Structure-Based Optimization of Potent 4- and 6-Azaindole-3-Carboxamides as Renin Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-S53:
[7-benzyl-2-(5-fluoro-2-methylphenoxy)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl](piperazin-1-yl)methanone

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / RENIN HUMAN / ASPARTYL PROTEASE / RENIN INHIBITION / HYPERTENSION / beta barrel / pepsin-like protease / glycosylation / extracellular space / HYDROLASE-HYDROLASE INHIBITOR complex

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