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Structure paper

TitleCrystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
Journal, issue, pagesStructure, Vol. 19, Page 1074-1083, Year 2011
Publish dateJun 14, 2011 (structure data deposition date)
AuthorsReubold, T.F. / Wohlgemuth, S. / Eschenburg, S.
External linksStructure / PubMed:21827944
MethodsX-ray diffraction
Resolution3 - 3.55 Å
Structure data

PDB-3sfz:
Crystal structure of full-length murine Apaf-1
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-3shf:
Crystal structure of the R265S mutant of full-length murine Apaf-1
Method: X-RAY DIFFRACTION / Resolution: 3.55 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-GBL:
GAMMA-BUTYROLACTONE

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsAPOPTOSIS / caspase activation / cytochrome c / procaspase-9 / adenine nucleotide / cytosol / tandem beta-propeller

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