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TitleSynthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 13504-13509, Year 2011
Publish dateMar 23, 2011 (structure data deposition date)
AuthorsMorita, H. / Yamashita, M. / Shi, S.P. / Wakimoto, T. / Kondo, S. / Kato, R. / Sugio, S. / Kohno, T. / Abe, I.
External linksProc. Natl. Acad. Sci. USA / PubMed:21825160
MethodsX-ray diffraction
Resolution2 - 2.2 Å
Structure data

PDB-3awj:
Crystal structure of the Huperzia serrata polyketide synthase 1 complexed with CoA-SH
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3awk:
Crystal structure of the polyketide synthase 1 from huperzia serrata
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-COA:
COENZYME A

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • huperzia serrata (toothed club-moss)
KeywordsTRANSFERASE / type III polyketide synthase / chalcone synthase

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