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Structure paper

TitleSimultaneous binding of two peptidyl ligands by a SRC homology 2 domain.
Journal, issue, pagesBiochemistry, Vol. 50, Page 7637-7646, Year 2011
Publish dateAug 29, 2011 (structure data deposition date)
AuthorsZhang, Y. / Zhang, J. / Yuan, C. / Hard, R.L. / Park, I.H. / Li, C. / Bell, C. / Pei, D.
External linksBiochemistry / PubMed:21800896
MethodsX-ray diffraction
Resolution1.8 - 2.05 Å
Structure data

PDB-3tkz:
Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3tl0:
Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE/Peptide / SH2 domain / Protein Protein Interactions / PTR Residues / HYDROLASE-Peptide complex / Protein-protein interactions / phosphorylated tyrosine

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