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-Structure paper
| Title | Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. |
|---|---|
| Journal, issue, pages | J. Am. Chem. Soc., Vol. 133, Page 12474-12477, Year 2011 |
| Publish date | Apr 28, 2011 (structure data deposition date) |
Authors | Cole, K.E. / Dowling, D.P. / Boone, M.A. / Phillips, A.J. / Christianson, D.W. |
External links | J. Am. Chem. Soc. / PubMed:21790156 |
| Methods | X-ray diffraction |
| Resolution | 2.143 Å |
| Structure data | ![]() PDB-3rqd: |
| Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-K: ![]() ChemComp-HOH: |
| Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / histone deacetylase / largazole / histone deacetylation / HYDROLASE-HYDROLASE INHIBITOR complex |
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homo sapiens (human)
symploca (bacteria)
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