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Structure paper

TitleStructural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 31676-31683, Year 2011
Publish dateApr 16, 2009 (structure data deposition date)
AuthorsZhou, H. / Zha, Z. / Liu, Y. / Zhang, H. / Zhu, J. / Hu, S. / Shen, G. / Cheng, L. / Niu, L. / Greene, M.I. ...Zhou, H. / Zha, Z. / Liu, Y. / Zhang, H. / Zhu, J. / Hu, S. / Shen, G. / Cheng, L. / Niu, L. / Greene, M.I. / Teng, M. / Liu, J.
External linksJ. Biol. Chem. / PubMed:21680730
MethodsX-ray diffraction
Resolution2.45 Å
Structure data

PDB-3h3b:
Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / immunoglobulin / beta-helix / protein-protein complex / ATP-binding / Disulfide bond / Kinase / Nucleotide-binding / Receptor / Transferase / Transmembrane / Tyrosine-protein kinase

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