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Structure paper

TitlePrinciples of activation and permeation in an anion-selective Cys-loop receptor.
Journal, issue, pagesNature, Vol. 474, Page 54-60, Year 2011
Publish dateApr 12, 2011 (structure data deposition date)
AuthorsHibbs, R.E. / Gouaux, E.
External linksNature / PubMed:21572436
MethodsX-ray diffraction
Resolution3.26 - 3.8 Å
Structure data

PDB-3rhw:
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin
Method: X-RAY DIFFRACTION / Resolution: 3.26 Å

PDB-3ri5:
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-3ria:
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide.
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

PDB-3rif:
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate.
Method: X-RAY DIFFRACTION / Resolution: 3.345 Å

Chemicals

ChemComp-IVM:
(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 / antiparasitic*YM

ChemComp-LMT:
DODECYL-BETA-D-MALTOSIDE / detergent*YM

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-OCT:
N-OCTANE

ChemComp-UND:
UNDECANE

ChemComp-CL:
Unknown entry

ChemComp-RI5:
(1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c / toxin*YM

ChemComp-IOD:
IODIDE ION

ChemComp-GLU:
GLUTAMIC ACID

Source
  • caenorhabditis elegans (invertebrata)
  • mus musculus (house mouse)
Keywordstransport protein/immune system / Membrane protein / transport protein / Cys-loop receptor / ligand-gated ion channel / neurotransmitter receptor / Ivermectin / Picrotoxin / Glycosylation / transport protein-immune system complex

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