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Structure paper

TitlePhosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 25246-25255, Year 2011
Publish dateOct 22, 2009 (structure data deposition date)
AuthorsZahn, K.E. / Tchesnokov, E.P. / Gotte, M. / Doublie, S.
External linksJ. Biol. Chem. / PubMed:21566148
MethodsX-ray diffraction
Resolution2.66 - 2.69 Å
Structure data

PDB-3kd1:
Closed binary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair.
Method: X-RAY DIFFRACTION / Resolution: 2.66 Å

PDB-3kd5:
Closed ternary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair and phosphonoformic acid.
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PPF:
PHOSPHONOFORMIC ACID / medication, antivirus, inhibitor*YM

Source
  • enterobacteria phage rb69 (virus)
KeywordsTRANSFERASE/DNA / gp43 / polymerase / HCMV / human cytomegalovirus / acyclovir / acyclic guanosine / foscavir / foscarnet / phosphonoformic acid / DNA replication / DNA-binding / DNA-directed DNA polymerase / Exonuclease / Hydrolase / Nuclease / Nucleotidyltransferase / Transferase / TRANSFERASE-DNA COMPLEX / antiviral

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