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TitleBinding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 8628-8633, Year 2011
Publish dateNov 16, 2010 (structure data deposition date)
AuthorsZarpellon, A. / Celikel, R. / Roberts, J.R. / McClintock, R.A. / Mendolicchio, G.L. / Moore, K.L. / Jing, H. / Varughese, K.I. / Ruggeri, Z.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:21555542
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-3pmh:
Mechanism of Sulfotyrosine-Mediated Glycoprotein Ib Interaction with Two Distinct alpha-Thrombin Sites
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-0G7:
D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
Keywordsblood cloting / hydrolase/inhibitor / Sulfated tyrosine residues / Leucine Rich Repeats / Protease Platelet receptor of thrombin / Thrombin binding / Platelet surface / hydrolase-inhibitor complex

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