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TitleIwr1 directs RNA polymerase II nuclear import.
Journal, issue, pagesMol Cell, Vol. 42, Issue 2, Page 261-266, Year 2011
Publish dateApr 22, 2011
AuthorsElmar Czeko / Martin Seizl / Christian Augsberger / Thorsten Mielke / Patrick Cramer /
PubMed AbstractRNA polymerase (Pol) II transcribes protein-coding genes in the nucleus of eukaryotic cells and consists of 12 polypeptide subunits. It is unknown how Pol II is imported into the nucleus. Here we ...RNA polymerase (Pol) II transcribes protein-coding genes in the nucleus of eukaryotic cells and consists of 12 polypeptide subunits. It is unknown how Pol II is imported into the nucleus. Here we show that Pol II nuclear import requires the protein Iwr1 and provide evidence for cyclic Iwr1 function. Iwr1 binds Pol II in the active center cleft between the two largest subunits, maybe facilitating or sensing complete Pol II assembly in the cytoplasm. Iwr1 then uses an N-terminal bipartite nuclear localization signal that is recognized by karyopherin α to direct Pol II nuclear import. In the nucleus, Iwr1 is displaced from Pol II by transcription initiation factors and nucleic acids, enabling its export and recycling. Iwr1 function is Pol II specific, transcription independent, and apparently conserved from yeast to human.
External linksMol Cell / PubMed:21504834
MethodsEM (single particle)
Resolution20.9 Å
Structure data

EMDB-1883:
Three-dimensional structure of the RNA polymerase II-Iwr1 complex
Method: EM (single particle) / Resolution: 20.9 Å

Source
  • Saccharomyces cerevisiae (brewer's yeast)

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