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Structure paper

TitleStructural Basis for a New Tetracycline Resistance Mechanism Relying on the Tetx Monooxygenase.
Journal, issue, pagesFEBS Lett., Vol. 585, Page 1061-, Year 2011
Publish dateMay 5, 2010 (structure data deposition date)
AuthorsVolkers, G. / Palm, G.J. / Weiss, M.S. / Wright, G.D. / Hinrichs, W.
External linksFEBS Lett. / PubMed:21402075
MethodsX-ray diffraction
Resolution2.09 - 3.1 Å
Structure data

PDB-2xdo:
Structure of the Tetracycline degrading Monooxygenase TetX2 from Bacteroides thetaiotaomicron
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-2xyo:
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-2y6q:
Structure of the TetX monooxygenase in complex with the substrate 7- Iodtetracycline
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-2y6r:
Structure of the TetX monooxygenase in complex with the substrate 7- chlortetracycline
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-I7T:
7-IODOTETRACYCLINE

ChemComp-CTC:
7-CHLOROTETRACYCLINE / antibiotic*YM

Source
  • bacteroides thetaiotaomicron (bacteria)
KeywordsOXIDOREDUCTASE / TETRACYCLINE DEGRADATION / TIGECYCLINE / FLAVIN / BACTEROIDES FRAGILI / ANTIBIOTIC RESISTANCE / MONOOXYGENASE

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