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-Structure paper
Title | Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 1942-1947, Year 2011 |
Publish date | Nov 5, 2010 (structure data deposition date) |
Authors | Rueeger, H. / Rondeau, J.M. / McCarthy, C. / Mobitz, H. / Tintelnot-Blomley, M. / Neumann, U. / Desrayaud, S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:21388807 |
Methods | X-ray diffraction |
Resolution | 2.24 - 2.4 Å |
Structure data | PDB-3pi5: PDB-3qbh: |
Chemicals | ChemComp-3P5: ChemComp-HOH: ChemComp-QBH: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / Enzyme inhibitor complex / Aspartic proteinase / Hydrolase-Hydrolase Inhibitor complex / HYDROLASE |