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-Structure paper
| Title | Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 54, Page 1836-1846, Year 2011 |
| Publish date | Jan 7, 2011 (structure data deposition date) |
 Authors | Gould, A.E. / Adams, R. / Adhikari, S. / Aertgeerts, K. / Afroze, R. / Blackburn, C. / Calderwood, E.F. / Chau, R. / Chouitar, J. / Duffey, M.O. ...Gould, A.E. / Adams, R. / Adhikari, S. / Aertgeerts, K. / Afroze, R. / Blackburn, C. / Calderwood, E.F. / Chau, R. / Chouitar, J. / Duffey, M.O. / England, D.B. / Farrer, C. / Forsyth, N. / Garcia, K. / Gaulin, J. / Greenspan, P.D. / Guo, R. / Harrison, S.J. / Huang, S.C. / Iartchouk, N. / Janowick, D. / Kim, M.S. / Kulkarni, B. / Langston, S.P. / Liu, J.X. / Ma, L.T. / Menon, S. / Mizutani, H. / Paske, E. / Renou, C.C. / Rezaei, M. / Rowland, R.S. / Sintchak, M.D. / Smith, M.D. / Stroud, S.G. / Tregay, M. / Tian, Y. / Veiby, O.P. / Vos, T.J. / Vyskocil, S. / Williams, J. / Xu, T. / Yang, J.J. / Yano, J. / Zeng, H. / Zhang, D.M. / Zhang, Q. / Galvin, K.M. |
 External links | J. Med. Chem. / PubMed:21341678 |
| Methods | X-ray diffraction |
| Resolution | 3.1 Å |
| Structure data |  PDB-3q96: |
| Chemicals |  ChemComp-0NF: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Design / Optimization / Potent / Orally Bioavailable / Tetrahydronaphthalene / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)