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Structure paper

TitleCrystal Structure of R120G Disease Mutant of Human Alphab-Crystallin Domain Dimer Shows Closure of a Groove
Journal, issue, pagesJ. Mol. Biol., Vol. 408, Page 118-, Year 2011
Publish dateDec 10, 2010 (structure data deposition date)
AuthorsClark, A.R. / Naylor, C.E. / Bagneris, C. / Keep, N.H. / Slingsby, C.
External linksJ. Mol. Biol. / PubMed:21329698
MethodsX-ray diffraction
Resolution2 - 3.7 Å
Structure data

PDB-2y1y:
Human alphaB crystallin ACD(residues 71-157)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2y1z:
Human alphaB Crystallin ACD R120G
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2y22:
Human AlphaB-crystallin Domain (residues 67-157)
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

Chemicals

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsCHAPERONE / SMALL HEAT SHOCK PROTEIN / STRESS PROTEIN / EYE LENS PROTEIN / CATARACT

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