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Structure paper

TitleStructures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Journal, issue, pagesScience, Vol. 330, Page 1816-, Year 2010
Publish dateNov 1, 2010 (structure data deposition date)
AuthorsForneris, F. / Ricklin, D. / Wu, J. / Tzekou, A. / Wallace, R.S. / Lambris, J.D. / Gros, P.
External linksScience / PubMed:21205667
MethodsX-ray diffraction
Resolution1.2 - 4 Å
Structure data

PDB-2xw9:
Crystal Structure of Complement Factor D mutant S183A
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-2xwa:
Crystal Structure of Complement Factor D Mutant R202A
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2xwb:
Crystal Structure of Complement C3b in complex with Factors B and D
Method: X-RAY DIFFRACTION / Resolution: 3.49 Å

PDB-2xwj:
Crystal Structure of Complement C3b in Complex with Factor B
Method: X-RAY DIFFRACTION / Resolution: 4 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NI:
NICKEL (II) ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE / IMMUNE SYSTEM / SERINE PROTEASE / ALTERNATIVE PATHWAY / PRO-CONVERTASE / CONFORMATIONAL CHANGES

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