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Structure paper

TitleElicitation of structure-specific antibodies by epitope scaffolds.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 107, Page 17880-17887, Year 2010
Publish dateJan 15, 2010 (structure data deposition date)
AuthorsOfek, G. / Guenaga, F.J. / Schief, W.R. / Skinner, J. / Baker, D. / Wyatt, R. / Kwong, P.D.
External linksProc. Natl. Acad. Sci. USA / PubMed:20876137
MethodsX-ray diffraction
Resolution1.97 - 2.77 Å
Structure data

PDB-3les:
2F5 Epitope scaffold ES2
Method: X-RAY DIFFRACTION / Resolution: 2.77 Å

PDB-3lev:
HIV-1 antibody 2F5 in complex with epitope scaffold ES2
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3lex:
2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-3ley:
2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 6a7 in complex with HIV-1 GP41
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-GOL:
GLYCEROL

ChemComp-ZN:
Unknown entry

Source
  • thermus aquaticus (bacteria)
  • homo sapiens (human)
  • mus musculus (house mouse)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / HIV-1 / GP41 / MONOCLONAL ANTIBODY / 2F5 / EPITOPE / TRANSPLANT / SCAFFOLD / GRAFT / SIGMA FACTOR / RE-ELICITATION / VACCINE DESIGN / GP-41 / RE-ELCITATION / Envelope protein

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