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TitleDiphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
Journal, issue, pagesNature, Vol. 465, Page 891-896, Year 2010
Publish dateMar 1, 2010 (structure data deposition date)
AuthorsZhang, Y. / Zhu, X. / Torelli, A.T. / Lee, M. / Dzikovski, B. / Koralewski, R.M. / Wang, E. / Freed, J. / Krebs, C. / Ealick, S.E. / Lin, H.
External linksNature / PubMed:20559380
MethodsX-ray diffraction
Resolution2.1 - 2.261 Å
Structure data

PDB-3lzc:
Crystal structure of Dph2 from Pyrococcus horikoshii
Method: X-RAY DIFFRACTION / Resolution: 2.261 Å

PDB-3lzd:
Crystal structure of Dph2 from Pyrococcus horikoshii with 4Fe-4S cluster
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-SO4:
SULFATE ION

Source
  • pyrococcus horikoshii (archaea)
KeywordsBIOSYNTHETIC PROTEIN / Diphthamide biosynthesis / radical SAM enzyme / gene triplication / iron-sulfur cluster

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