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-Structure paper
Title | Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 107, Page 11313-11318, Year 2010 |
Publish date | Aug 4, 2009 (structure data deposition date) |
Authors | Cho, Y. / Crichlow, G.V. / Vermeire, J.J. / Leng, L. / Du, X. / Hodsdon, M.E. / Bucala, R. / Cappello, M. / Gross, M. / Gaeta, F. ...Cho, Y. / Crichlow, G.V. / Vermeire, J.J. / Leng, L. / Du, X. / Hodsdon, M.E. / Bucala, R. / Cappello, M. / Gross, M. / Gaeta, F. / Johnson, K. / Lolis, E.J. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:20534506 |
Methods | X-ray diffraction |
Resolution | 1.25 - 1.7 Å |
Structure data | PDB-3ijg: PDB-3ijj: |
Chemicals | ChemComp-CL: ChemComp-AVR: ChemComp-HOH: ChemComp-EN1: ChemComp-ENO: |
Source |
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Keywords | ISOMERASE / allosteric binding / Cytokine / Immune response / Inflammatory response / Innate immunity / Phosphoprotein / Secreted / allosteric inhibition |