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Structure paper

TitleStructural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
Journal, issue, pagesEmbo J., Vol. 29, Page 2059-2069, Year 2010
Publish dateMar 22, 2010 (structure data deposition date)
AuthorsWong, J.H. / Brown, J.A. / Suo, Z. / Blum, P. / Nohmi, T. / Ling, H.
External linksEmbo J. / PubMed:20512114
MethodsX-ray diffraction
Resolution1.93 - 2.9 Å
Structure data

PDB-3m9m:
Crystal Structure of Dpo4 in complex with DNA containing the major cisplatin lesion
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3m9n:
Crystal Structure of Dpo4 in complex with DNA containing the major cisplatin lesion
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-3m9o:
Crystal Structure of Dpo4 in complex with DNA containing the major cisplatin lesion
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-CTP:
CYTIDINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-CPT:
Cisplatin / medication, chemotherapy*YM

ChemComp-HOH:
WATER

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Source
  • sulfolobus solfataricus (archaea)
  • synthetic construct (others)
KeywordsTransferase/DNA / Dpo4 / translesion DNA synthesis / TLS / cisplatin / Y-family DNA polymerase / protein-DNA complex / DNA / DNA damage / DNA repair / DNA replication / DNA-binding / DNA-directed DNA polymerase / Magnesium / Metal-binding / Mutator protein / Nucleotidyltransferase / Transferase / Transferase-DNA complex

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