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TitleA novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Journal, issue, pagesNature, Vol. 465, Page 641-644, Year 2010
Publish dateDec 20, 2009 (structure data deposition date)
AuthorsSchmidt, B.H. / Burgin, A.B. / Deweese, J.E. / Osheroff, N. / Berger, J.M.
External linksNature / PubMed:20485342
MethodsX-ray diffraction
Resolution2.48 - 2.98 Å
Structure data

PDB-3l4j:
Topoisomerase II-DNA cleavage complex, apo
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

PDB-3l4k:
Topoisomerase II-DNA cleavage complex, metal-bound
Method: X-RAY DIFFRACTION / Resolution: 2.98 Å

Chemicals

ChemComp-TSP:
3'-THIO-THYMIDINE-5'-PHOSPHATE

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsIsomerase/DNA / TOPOISOMERASE / PROTEIN-DNA COMPLEX / COVALENTLY LINKED COMPLEX / DNA SUPERCOILING / DNA REPLICATION / ATP-binding / DNA-binding / Isomerase / Nucleotide-binding / Nucleus / Phosphoprotein / Isomerase-DNA complex

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