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TitleStructural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole
Journal, issue, pagesPlos Negl Trop Dis, Vol. 4, Page E651-, Year 2010
Publish dateOct 11, 2009 (structure data deposition date)
AuthorsChen, C.-K. / Leung, S.S.F. / Guilbert, C. / Jacobson, M. / Mckerrow, J.H. / Podust, L.M.
External linksPlos Negl Trop Dis / PubMed:20386598
MethodsX-ray diffraction
Resolution2.27 - 2.7 Å
Structure data

PDB-2wuz:
X-ray structure of CYP51 from Trypanosoma cruzi in complex with fluconazole in alternative conformation
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-2wv2:
X-ray structure of CYP51 from the human pathogen Trypanosoma brucei in complex with fluconazole
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-2wx2:
X-RAY STRUCTURE OF CYP51 FROM THE HUMAN PATHOGEN TRYPANOSOMA CRUZI IN COMPLEX WITH FLUCONAZOLE
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

PDB-2x2n:
X-ray structure of cyp51 from trypanosoma brucei in complex with posaconazole in two different conformations
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-TPF:
2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL / medication*YM

ChemComp-HOH:
WATER

ChemComp-X2N:
POSACONAZOLE / medication, antifungal*YM

Source
  • trypanosoma cruzi (eukaryote)
  • trypanosoma brucei (eukaryote)
KeywordsOXIDOREDUCTASE / METHYLTRANSFERASE / P450 / IRON / CYP51 / METAL-BINDING / ERGOSTEROL BIOSYNTHESIS / HEME

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