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TitleN-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.
Journal, issue, pagesNature, Vol. 464, Page 728-, Year 2010
Publish dateSep 4, 2009 (structure data deposition date)
AuthorsFrearson, J.A. / Brand, S. / McElroy, S.P. / Cleghorn, L.A. / Smid, O. / Stojanovski, L. / Price, H.P. / Guther, M.L. / Torrie, L.S. / Robinson, D.A. ...Frearson, J.A. / Brand, S. / McElroy, S.P. / Cleghorn, L.A. / Smid, O. / Stojanovski, L. / Price, H.P. / Guther, M.L. / Torrie, L.S. / Robinson, D.A. / Hallyburton, I. / Mpamhanga, C.P. / Brannigan, J.A. / Wilkinson, A.J. / Hodgkinson, M. / Hui, R. / Qiu, W. / Raimi, O.G. / van Aalten, D.M. / Brenk, R. / Gilbert, I.H. / Read, K.D. / Fairlamb, A.H. / Ferguson, M.A. / Smith, D.F. / Wyatt, P.G.
External linksNature / PubMed:20360736
MethodsX-ray diffraction
Resolution1.49 - 1.6 Å
Structure data

PDB-2wsa:
Crystal Structure of Leishmania major N-myristoyltransferase (NMT) with bound myristoyl-CoA and a pyrazole sulphonamide ligand (DDD85646)
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-3h5z:
Crystal Structure of Leishmania major N-myristoyltransferase with bound myristoyl-CoA
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

Chemicals

ChemComp-MYA:
TETRADECANOYL-COA

ChemComp-646:
2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-UNX:
Unknown entry

Source
  • leishmania major (eukaryote)
KeywordsTRANSFERASE / ACYLTRANSFERASE / DRUG DISCOVERY / N-myristoyltransferase / NMT / Leishmania major / structural genomics / Structural Genomics Consortium / SGC

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