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TitleA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 17, Page 519-527, Year 2010
Publish dateSep 30, 2009 (structure data deposition date)
AuthorsWojcik, J. / Hantschel, O. / Grebien, F. / Kaupe, I. / Bennett, K.L. / Barkinge, J. / Jones, R.B. / Koide, A. / Superti-Furga, G. / Koide, S.
External linksNat. Struct. Mol. Biol. / PubMed:20357770
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-3k2m:
Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/PROTEIN BINDING / Engineered Binding Protein / Antibody Mimic / Protein-Protein complex / SH2 domain / ATP-binding / Phosphoprotein / Tyrosine-protein kinase / SIGNALING PROTEIN / SIGNALING PROTEIN-PROTEIN BINDING COMPLEX

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