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TitleImproving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.
Journal, issue, pagesProtein Sci., Vol. 19, Page 954-966, Year 2010
Publish dateDec 6, 2009 (structure data deposition date)
AuthorsPepinsky, R.B. / Silvian, L. / Berkowitz, S.A. / Farrington, G. / Lugovskoy, A. / Walus, L. / Eldredge, J. / Capili, A. / Mi, S. / Graff, C. / Garber, E.
External linksProtein Sci. / PubMed:20198683
MethodsX-ray diffraction
Resolution2.62 - 3.2 Å
Structure data

PDB-3kyk:
Crystal structure of li33 Igg1 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-3kym:
Crystal structure of Li33 IgG2 di-Fab
Method: X-RAY DIFFRACTION / Resolution: 2.62 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody / IgG2 monoclonal anti-Lingo

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