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TitleStructural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab
Journal, issue, pagesJ. Immunol., Vol. 184, Page 1361-1368, Year 2010
Publish dateAug 29, 2009 (structure data deposition date)
AuthorsDu, J. / Yang, H. / Zhang, D. / Wang, J. / Guo, H. / Peng, B. / Guo, Y. / Ding, J.
External linksJ. Immunol. / PubMed:20032294
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-3iu3:
Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IL-2Ra / CD25 / Basiliximab / Simulect / therapeutic antibody / Disulfide bond / Glycoprotein / Membrane / Receptor / Sushi / Transmembrane

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