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Structure paper

TitleA Single Mutation at the Sheet Switch Region Results in Conformational Changes Favoring Lambda6 Light-Chain Fibrillogenesis.
Journal, issue, pagesJ. Mol. Biol., Vol. 396, Page 280-, Year 2010
Publish dateAug 19, 2008 (structure data deposition date)
AuthorsHernandez-Santoyo, A. / Del Pozo Yauner, L. / Fuentes-Silva, D. / Ortiz, E. / Rudino-Pinera, E. / Sanchez-Lopez, R. / Horjales, E. / Becerril, B. / Rodriguez-Romero, A.
External linksJ. Mol. Biol. / PubMed:19941869
MethodsX-ray diffraction
Resolution1.9 - 2.35 Å
Structure data

PDB-2w0k:
Crystal structure of the recombinant variable domain 6JAL2
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-3b5g:
Crystal Structure of the Unstable and Highly Fibrillogenic PRO7SER Mutant of the Recombinant Variable Domain 6AJL2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3bdx:
Crystal structure of the unstable and highly fibrillogenic Pro7Ser mutant of the Recombinant variable domain 6AJL2
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / FIBRILS / GERM LINE / ANTIBODIES / FIBRINOGENIC / Lambda VI subgroup / light chain variable domain / beta-sandwich / immunoglobulin / AL amyloidosis

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