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TitleKIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.
Journal, issue, pagesJ. Exp. Med., Vol. 206, Page 2557-2572, Year 2009
Publish dateApr 29, 2009 (structure data deposition date)
AuthorsGraef, T. / Moesta, A.K. / Norman, P.J. / Abi-Rached, L. / Vago, L. / Older Aguilar, A.M. / Gleimer, M. / Hammond, J.A. / Guethlein, L.A. / Bushnell, D.A. ...Graef, T. / Moesta, A.K. / Norman, P.J. / Abi-Rached, L. / Vago, L. / Older Aguilar, A.M. / Gleimer, M. / Hammond, J.A. / Guethlein, L.A. / Bushnell, D.A. / Robinson, P.J. / Parham, P.
External linksJ. Exp. Med. / PubMed:19858347
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3h8n:
Crystal Structure Analysis of KIR2DS4
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ligand-binding domains / Cell membrane / Disulfide bond / Glycoprotein / Immunoglobulin domain / Membrane / Polymorphism / Receptor / Transmembrane

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