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Structure paper

TitleStructure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin.
Journal, issue, pagesAntimicrob. Agents Chemother., Vol. 54, Page 267-272, Year 2010
Publish dateJul 27, 2009 (structure data deposition date)
AuthorsHeinemann, I.U. / Schulz, C. / Schubert, W.D. / Heinz, D.W. / Wang, Y.G. / Kobayashi, Y. / Awa, Y. / Wachi, M. / Jahn, D. / Jahn, M.
External linksAntimicrob. Agents Chemother. / PubMed:19822707
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-2woq:
Porphobilinogen Synthase (HemB) in Complex with 5-acetamido-4- oxohexanoic acid (Alaremycin 2)
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-AYC:
ALAREMYCIN 2

ChemComp-MG:
Unknown entry

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-PE5:
3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • pseudomonas aeruginosa (bacteria)
KeywordsLYASE/ANTIBIOTIC / LYASE-ANTIBIOTIC COMPLEX / LYASE ANTIBIOTIC COMPLEX / METAL-BINDING / HEME BIOSYNTHESIS / PORPHYRIN BIOSYNTHESIS / PORPOBILINOGEN SYNTHASE / HEMB / LYASE / INHIBITOR

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