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TitleThe crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 106, Page 17717-17722, Year 2009
Publish dateJul 10, 2009 (structure data deposition date)
AuthorsWojciak, J.M. / Zhu, N. / Schuerenberg, K.T. / Moreno, K. / Shestowsky, W.S. / Hiraiwa, M. / Sabbadini, R. / Huxford, T.
External linksProc. Natl. Acad. Sci. USA / PubMed:19815502
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-3i9g:
Crystal structure of the LT1009 (SONEPCIZUMAB) antibody Fab fragment in complex with sphingosine-1-phosphate
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-S1P:
(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Antibody / Fab / Sphingosine-1-phosphate / Calcium / Immunoglobin / IgG

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