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Structure paper

TitleA frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 106, Page 16996-17001, Year 2009
Publish dateMay 15, 2009 (structure data deposition date)
AuthorsMandelker, D. / Gabelli, S.B. / Schmidt-Kittler, O. / Zhu, J. / Cheong, I. / Huang, C.H. / Kinzler, K.W. / Vogelstein, B. / Amzel, L.M.
External linksProc. Natl. Acad. Sci. USA / PubMed:19805105
MethodsX-ray diffraction
Resolution2.8 - 3.3 Å
Structure data

PDB-3hhm:
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-3hiz:
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-KWT:
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/ONCOPROTEIN / p110 / p85 / PI3KCA / PI3K / PIK3R1 / phosphatidilynositol 3 / 4 / 5-triphosphate / wortmannin / H1047R / ATP-binding / Disease mutation / Kinase / Nucleotide-binding / Oncogene / Polymorphism / Transferase / TRANSFERASE-ONCOPROTEIN COMPLEX / Alternative splicing / Host-virus interaction / Phosphoprotein / SH2 domain / SH3 domain / Ubl conjugation

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