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Structure paper

TitleInsights into complement convertase formation based on the structure of the factor B-cobra venom factor complex
Journal, issue, pagesEmbo J., Vol. 28, Page 2469-2478, Year 2009
Publish dateJun 10, 2009 (structure data deposition date)
AuthorsJanssen, B.J. / Gomes, L. / Koning, R.I. / Svergun, D.I. / Koster, A.J. / Fritzinger, D.C. / Vogel, C.W. / Gros, P.
External linksEmbo J. / PubMed:19574954
MethodsX-ray diffraction
Resolution2.2 - 3 Å
Structure data

PDB-3hrz:
Cobra Venom Factor (CVF) in complex with human factor B
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3hs0:
Cobra Venom Factor (CVF) in complex with human factor B
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • naja kaouthia (monocled cobra)
KeywordsIMMUNE SYSTEM / serine protease / glycosilated / multi-domain / complement system / convertase / Complement alternate pathway / Complement pathway / Disulfide bond / Glycoprotein / Immune response / Inflammatory response / Innate immunity / Secreted / Thioester bond / Cleavage on pair of basic residues / Glycation / Hydrolase / Protease / Sushi / Zymogen

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