EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.
ジャーナル・号・ページ	J. Med. Chem., Vol. 52, Page 4810-, Year 2009
掲載日	2009年7月3日 (構造データの登録日)
著者	Matthews, T.P. / Klair, S. / Burns, S. / Boxall, K. / Cherry, M. / Fisher, M. / Westwood, I.M. / Walton, M.I. / Mchardy, T. / Cheung, K.-M.J. ...Matthews, T.P. / Klair, S. / Burns, S. / Boxall, K. / Cherry, M. / Fisher, M. / Westwood, I.M. / Walton, M.I. / Mchardy, T. / Cheung, K.-M.J. / Van Montfort, R. / Williams, D. / Aherne, G.W. / Garrett, M.D. / Reader, J. / Collins, I.
リンク	J. Med. Chem. / PubMed:19572549
手法	X線回折
解像度	2.009 - 2.7 Å
構造データ	PDB-2wmq: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.48 Å PDB-2wmr: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å PDB-2wms: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-2wmt: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.55 Å PDB-2wmu: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-2wmv: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.009 Å PDB-2wmw: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å PDB-2wmx: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å
化合物	ChemComp-ZYQ: N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE ChemComp-HOH: WATER ChemComp-ZYR: 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE / 3,4,5,6,7,8-ヘキサヒドロ[1]ベンゾチエノ[2,3-d]ピリミジン-4-オン ChemComp-ZYS: [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone ChemComp-ZYT: 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol ChemComp-ZYU: 6-MORPHOLIN-4-YL-9H-PURINE / 6-モルホリノ-9H-プリン ChemComp-ZYV: 1-[(2S)-4-(7H-PURIN-6-YL)MORPHOLIN-2-YL]METHANAMINE ChemComp-ZYW: 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE ChemComp-ZY6: 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / POLYMORPHISM / PHOSPHOPROTEIN / UBL CONJUGATION / ISOPEPTIDE BOND / CHECKPOINT KINASE / NUCLEOTIDE-BINDING / SERINE/THREONINE KINASE / DNA DAMAGE / DNA REPAIR / ATP-BINDING / CHK1 / KINASE / NUCLEUS / CYTOPLASM / CELL CYCLE