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Structure paper

TitleUnusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 24478-, Year 2009
Publish dateJul 10, 2008 (structure data deposition date)
AuthorsArgiriadi, M.A. / Xiang, T. / Wu, C. / Ghayur, T. / Borhani, D.W.
External linksJ. Biol. Chem. / PubMed:19553661
MethodsX-ray diffraction
Resolution1.49 - 2.36 Å
Structure data

PDB-2vxt:
Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-2vxu:
Crystal structure of murine reference antibody 125-2H Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

PDB-2vxv:
Crystal structure of human IgG ABT-325 Fab Fragment
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CXS:
3-CYCLOHEXYL-1-PROPYLSULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsCYTOKINE / FAB / IL-18 / SECRETED / AUTOIMMUNITY / GLYCOPROTEIN / TH1/TH2 CELLS / IMMUNOGLOBULIN DOMAIN / IMMUNOGLOBULIN V REGION / IMMUNE SYSTEM

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