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TitleDecreased sensitivity to changes in the concentration of metal ions as the basis for the hyperactivity of DtxR(E175K).
Journal, issue, pagesJ. Mol. Biol., Vol. 390, Page 112-123, Year 2009
Publish dateMar 12, 2009 (structure data deposition date)
AuthorsD'Aquino, J.A. / Denninger, A.R. / Moulin, A.G. / D'Aquino, K.E. / Ringe, D.
External linksJ. Mol. Biol. / PubMed:19433095
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-3glx:
Crystal Structure Analysis of the DtxR(E175K) complexed with Ni(II)
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • corynebacterium diphtheriae (bacteria)
KeywordsTRANSCRIPTION / REPRESSOR / REGULATOR / DTXR / HELIX-TURN-HELIX / METAL ION / ACTIVATION / DNA-BINDING / FERROUS IRON / Cytoplasm / Transcriptional regulation / transcriptional regulator / Iron / Transcription regulation

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