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TitleDiscovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 2977-2980, Year 2009
Publish dateApr 8, 2009 (structure data deposition date)
AuthorsStachel, S.J. / Coburn, C.A. / Rush, D. / Jones, K.L. / Zhu, H. / Rajapakse, H. / Graham, S.L. / Simon, A. / Katharine Holloway, M. / Allison, T.J. ...Stachel, S.J. / Coburn, C.A. / Rush, D. / Jones, K.L. / Zhu, H. / Rajapakse, H. / Graham, S.L. / Simon, A. / Katharine Holloway, M. / Allison, T.J. / Munshi, S.K. / Espeseth, A.S. / Zuck, P. / Colussi, D. / Wolfe, A. / Pietrak, B.L. / Lai, M.T. / Vacca, J.P.
External linksBioorg. Med. Chem. Lett. / PubMed:19409780
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3h0b:
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-B35:
4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Aspartyl Protease / Alternative splicing / Disulfide bond / Glycoprotein / Membrane / Polymorphism / Protease / Transmembrane / Zymogen

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